Human Methionine Synthase

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Human methionine synthase reductase is a molecular chaperone for human methionine synthase.

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Defects in human methionine synthase in cblG patients.

Inborn errors resulting in isolated functional methionine synthase deficiency fall into two complementation groups, cblG and cblE. Using biochemical approaches we demonstrate that one cblG patient has greatly reduced levels of methionine synthase while in another, the enzyme is specifically impaired in the reductive activation cycle. The biochemical data suggested that low levels of methionine ...

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The Polymorphisms in Methylenetetrahydrofolate Reductase, Methionine Synthase, Methionine Synthase Reductase, and the Risk of Colorectal Cancer

Polymorphisms in genes involved in folate metabolism may modulate the risk of colorectal cancer (CRC), but data from published studies are conflicting. The current meta-analysis was performed to address a more accurate estimation. A total of 41 (17,552 cases and 26,238 controls), 24(8,263 cases and 12,033 controls), 12(3,758 cases and 5,646 controls), and 13 (5,511 cases and 7,265 controls) stu...

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Methionine synthase and neural tube defects.

It has been indicated lately that higher plasma homocysteine is one of the risk factors in neural tube defects(NTDs) and vascular disease. Methionine synthase is a key enzyme in homocysteine metabolism. The defects of methionine synthase activity could result in hyperhomocysteinemia and methionine auxotrophy. The gene mutations of methionine synthase with the epidemiological studies of NTDs are...

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ژورنال

عنوان ژورنال: Journal of Biological Chemistry

سال: 1997

ISSN: 0021-9258

DOI: 10.1074/jbc.272.6.3628